Protein Microarrays chips used to identify Protein-Protein interactions contain immobilized

• A) DNA/RNA
• B) carbohydrates
• C) Proteome
• D) amino acid

Protein are separated on the basis of molecular weight and charge (isoelectric point) through

• A) NMR
• B) X-Ray crystallography
• C) One dimensional gel electrophoresis
• D) 2D-gel electrophoresis

___is new science about how the systematic identification of all the human genes, their products, interindividual variation, intraindividual variation in expression and function over time affects drug response/metabolism etc.

• A) none
• B) Pharmacogentics
• C) both
• D) Pharmacogenomics

The process of process of adding information to DNA sequence is known as -------------?

• A) Genome wide association
• B) Express sequence tags
• C) Sequencing
• D) Genome annotation

A genetic map is based on -----------------?

• A) Physical distance between genes on chromosomes
• B) Polymorphic markers
• C) Recombination frequency
• D) Exon sequence

In the Ramachandran plot Most areas are

• A) none
• B) accessible
• C) forbidden
• D) both

is the study of how genetic variations affect the disposition of drugs, including their metabolism and transport and their safety and efficacy

• A) none
• B) both
• C) Pharmacogenetics
• D) Pharmacogenomics

The process by which a drug is absorbed, distributed, metabolized, and eliminated by the body tells its ---------- behaviour?

• A) Pharmocodynamic
• B) Pharmacokinetic
• C) Drug action
• D) Pharmaco-evolution

Which of the following is an incorrect statement about the terminologies related to protein sorting?

• A) Protein sorting is also known as protein targeting
• B) Subcellular localization is an integral part of protein functionality
• C) All the proteins exhibit functions after being transported to certain compartments of the cell
• D) Many proteins exhibit functions only after being transported to certain compartments of the cell

Separates proteins based on charge and mass

• A) both
• B) Mass Spectrometry (MS):
• C) 2D-Page Gel
• D) none

Inverse PCR uses standard PCR primers but they are oriented in the -------- direction of the usual orientation?

• A) Reverse
• B) complementary
• C) Forward
• D) One forward and one reverse

Which of the following type of PCR employ two pairs of primers to minimize non-specific amplification of PCR products -----------?

• A) Nested PCR
• B) Real time PCR
• C) Hot start PCR
• D) RT-PCR

The basic aim of human genome project was to -------------?

• A) Map the introns of genes
• B) Map the nucleotides contained in a human diploid reference genome
• C) Map the coding regions in human genome
• D) Map the nucleotides contained in a human haploid reference genome

Sequencing techniques that were used in Human Genome project are-----------?

• A) Next generation sequencing
• B) Sanger sequencing
• C) Both A and C
• D) Shotgun sequencing method

Genetic linkage is based on -------------?

• A) Orientation of chromosome
• B) Position of alleles on chromosomes
• C) Crossing over frequency
• D) Number of genes

One of the main limitation associated with RAPD is ---------?

• A) Work on anonymous genomes
• B) All of these
• C) Homozygotes and heterozygotes cannot be distinguished
• D) Highly expensive

Which of the following technique is different from conventional PCR because it need one primer for amplification ------------?

• A) Genome wide association studies
• B) RFLP
• C) ARMS-PCR
• D) RAPD

Which of the following studies the probability of an allele being identical by descent with itself ----------?

• A) Parametric linkage analysis
• B) Non-parametric linkage analysis
• C) Incomplete linkage
• D) Gene neighbours

Almost 90% of the structures in the protein data bank (PDB) were determine through?

• A) SDS PAGE
• B) X-ray Crystallography
• C) Mass Spectrometry
• D) Nuclear magnetic resonance imaging (NMR)

The human genome project was launched in 1990 by ----------?

• A) Genomic research center Canada
• B) Institute of Cancer research UK
• C) German center for genomics
• D) US Department of Energy and the National Institute of Health