MCQ Bank
The primary function of the pentose phosphate pathway is to produce
- A) Lactate and ATP
- B) Acetyl-CoA and NADH
- C) NADPH and ribose-5-phosphate
- D) ATP and pyruvate
Heinz bodies are formed due to:
- A) Lipid accumulation
- B) Hemoglobin denaturation
- C) Glycogen deposition
- D) DNA fragmentation
The high water-binding capacity of GAGs mainly contributes to:
- A) ATP synthesis in mitochondria
- B) Gel formation in the ECM
- C) Oxygen transport to the body
- D) Hormone secretion
Ribose-5-phosphate produced in the PPP is primarily required for
- A) Fatty acid synthesis
- B) Cholesterol synthesis
- C) Glycogen synthesis
- D) Nucleotide synthesis
The two major enzymes of the non-oxidative phase are
- A) G6PD and pyruvate kinase
- B) Aldolase and enolase
- C) Transketolase and transaldolase
- D) Hexokinase and phosphofructokinase
Which of the following is the key regulatory enzyme of the Pentose Phosphate Pathway?
- A) Glucose-6-phosphate dehydrogenase
- B) Hexokinase
- C) Pyruvate kinase
- D) Citrate synthase
Compression resistance in cartilage is largely due to the ability of GAGs to:
- A) Bind calcium ions
- B) Hydrolyze proteins
- C) Store glucose units
- D) Lose and regain water
Glycosaminoglycans are composed of repeating units of:
- A) Two hexose sugars
- B) Two phosphate sugars
- C) Amino sugar and acidic sugar
- D) Two amino acids
High cellular NADPH levels affect G6PD by
- A) Activating it
- B) Phosphorylating it
- C) Inhibiting it
- D) Degrading it
The reactions of the non-oxidative phase are
- A) Irreversible
- B) Reversible
- C) ATP-dependent only
- D) Oxygen-dependent
Increased demand for NADPH during oxidative stress will:
- A) Inhibit G6PD permanently
- B) Decrease NADP⁺ concentration
- C) Inhibit PPP activity
- D) Increase flux through the PPP
Which situation is most likely to precipitate hemolysis in a patient with G6PD deficiency?
- A) Oxidant drug exposure
- B) Increased water intake
- C) Regular exercise
- D) High-carbohydrate diet
The pentose phosphate pathway mainly utilizes
- A) Pyruvate
- B) Glucose-6-phosphate
- C) Fructose-6-phosphate
- D) Acetyl-CoA
G6PD deficiency follows which pattern of inheritance?
- A) Autosomal dominant
- B) Autosomal recessive
- C) Mitochondrial
- D) X-linked
High NADPH concentration causes:
- A) Increased ATP production
- B) Competitive inhibition of G6PD
- C) Activation of G6PD
- D) Increased glycolysis
The first enzyme of the oxidative phase is
- A) Pyruvate Transketolase
- B) Glucose Kinase
- C) Hexokinase
- D) Glucose-6-phosphate dehydrogenase