DNA Microarray technology is widely used for genetic analysis. The technique is basically an evolution of another process known as:

• A) Western blotting
• B) Southern hybridization
• C) Sanger sequencing
• D) Northern hybridization

Microarray technology evolved from ______, where fragmented DNA is attached to a substrate and then probed with a known DNA sequence.

• A) Southern blotting
• B) Northern blotting
• C) Western blotting
• D) Gel electrophoresis

Ensembl core databases store genome _________ information.

• A) Sequence
• B) RFLP
• C) Sequence and annotation
• D) SNPs

Ensembl is a joint project between these 3 organizations.

• A) EMBL, EBI, NCBI
• B) EMBL, EBI, FBI
• C) EMBL, EBI, WTSI
• D) EMBL, EBI, CIA

Mouse genome contains ___ CpG islands than human.

• A) equal
• B) permanent
• C) more
• D) fewer

Privacy and confidentiality of genetic information is a/an __________.

• A) Social and Legal
• B) Historical and Legal
• C) Ethical and Legal
• D) Biological and Legal

Arabidopsis Thaliana genomes has _____ genes and encodes _______ proteins.

• A) 35000, 35000
• B) 27000, 27000
• C) 2700, 3500
• D) 27000, 35000

The Human Genome Project raises complex ____ issues.

• A) Historical
• B) Ethical
• C) Biological
• D) Social

_______ is model plant from genome research.

• A) Convolvulus arvensis
• B) Typha latifolia
• C) Datura stramonium
• D) Arabidopsis Thaliana

Repeated sequences make up at least ______ of the human genome.

• A) 15 %
• B) 90 %
• C) 45 %
• D) 33 %

Approximately 40% of the human genome is same to the ______ genome.

• A) mouse
• B) cow
• C) dog
• D) drosophila

The genomes are so large that useful information is _______ to find.

• A) Easy
• B) Sufficient
• C) Accessible
• D) Hard

Which statement about DNA microarray is TRUE?

• A) The term RNA chipping is also used to describe the technique
• B) The principle of DNA microarray is based on the hybridization between sugar-phosphate backbone of the DNA molecules
• C) DNA microarray allows us to analyze thousands of genes in one experiment
• D) DNA microarray chips may be made of biodegradable plastic

There are several synonyms of DNA microarrays except _________.

• A) DNA arrays
• B) Linear arrays
• C) Gene chips
• D) Gene arrays

The mouse genome is about ____ smaller than the human genome.

• A) 50%
• B) 33%
• C) 14%
• D) 99%

Approximately ____ of mouse genes have a homologue in the human genome.

• A) 99%
• B) 10%
• C) 33%
• D) 50%

Genes can be identified in vitro using ______.

• A) Genomic methods
• B) Genomic selection
• C) Computational methods
• D) Genome sequencing

_____ is a model organism in Animal Biology and Genetics.

• A) Cow
• B) Drosophila
• C) Rat
• D) Mouse

Transcription factors are ________ that bind to the DNA and help to control gene expression.

• A) Proteins
• B) Amino acid
• C) cDNA
• D) RNA

DNA microarray has many applications. All of the following are applications of the technique EXCEPT:

• A) Assessment of gene expression levels
• B) Analysis of protein function
• C) Discovery of new genes
• D) Evaluation of micro RNA levels